ANI
23 Nov 2022, 21:37 GMT+10
Washington [US], November 23 (ANI): Researchers have discovered a protein that can predict whether or not DNA-damaging treatments will be effective when it is found in high concentrations in breast cancer tumors.
The findings were published in a paper titled 'Alterations in the p53 isoform ratio govern breast cancer cell fate in response to DNA damage' in the Cell DeathDisease journal.
Lead author of the study, HMRI and University of Newcastle PhD researcher Luiza Steffens-Reinhardt, said this work could lead to more effective chemotherapy for people with breast cancer.
"We looked at this particular variant of a protein called p53 because our previous studies have shown that it is present at high levels in breast cancer and is associated with cancer recurrence," she said.
"We were surprised to see that by increasing the levels of this variant of p53, the breast cancer cells became unresponsive to existing therapies. Thus, inhibiting this variant could enhance people's responses to currently used cancer treatments. We recently confirmed these findings in living subjects."Breast cancer affects more than 19,000 women every year in Australia and around one-quarter of these people develop treatment resistance.
"The primary reason women die from breast cancer is treatment resistance," said Ms Steffens-Reinhardt.
"A breast cancer that is resistant to treatment is impossible to cure. Therefore, there is an urgent need to improve therapies that target the cells responsible for resisting these therapies."Associate Professor Kelly Avery-Kiejda, who supervises Steffens-Reinhardt on her research, says, this research could be a first step in better targeting breast cancer treatment.
"One in eight women in Australia develop breast cancer and while there is a 92 per cent survival rate, this doesn't take into account secondary cancers or metastasis, which are essentially incurable," said Associate Professor Avery-Kiejda.
"If we can identify biomarkers that predict how well a patient will respond to certain therapies, we can then target the available therapies more effectively." (ANI)
Get a daily dose of Sydney Sun news through our daily email, its complimentary and keeps you fully up to date with world and business news as well.
Publish news of your business, community or sports group, personnel appointments, major event and more by submitting a news release to Sydney Sun.
More InformationWASHINGTON D.C.: A U.S. auto safety regulator said this week it is opening an investigation into 73,000 Chevrolet Volt plug-in ...
NEW YORK: This week, a New York judge approved legal settlements to end lawsuits that halted the state's legal cannabis ...
NEW YORK, New York - U.S. stocks spent most of Tuesday meandering, with the major indices closing out the day ...
DEARBORN, Michigan: This week, Ford said a six-week United Auto Workers (UAW) strike cut its sales by some 100,000 vehicles ...
WASHINGTON D.C.: This week, the Biden administration adopted a new rule aimed at reducing methane emissions, which targets the role ...
AUSTIN, Texas: During an event held this week in Austin, Texas, Tesla CEO Elon Musk said the electric vehicle (EV) ...
BOLOGNA, Italy: Due to fears of a collapse, local officials have secured the area around one of two 12th century ...
MUNICH, Germany: The heavy snow and icy conditions that hit Bavaria, Germany, canceled flights and long-distance trains out of Munich, ...
RALEIGH, North Carolina: After a decade of discussions and hesitations, North Carolina has expanded Medicaid coverage by offering government-funded health ...
The U.S. has supplied Israel with scores of BLU-109 bunker-buster bombs since October 7, the Wall Street Journal has reported, ...
WASHINGTON D.C.: This week, the Biden administration announced a proposal by the Environmental Protection Agency (EPA) that would require U.S. ...
TOKYO, Japan: Japan's space agency recently fell victim to a cyberattack, but reassuringly, the compromised information did not pertain to ...